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Keep track of Carefully (1)pentobarbital will minimize the level or impact of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Coadministration of fentanyl with CYP3A4 inducers may lead into a minimize in fentanyl plasma concentrations, insufficient efficacy or, perhaps, enhancement of